- This paper presents the agent-based model INFSO-SKIN, which provides ex-ante evaluation of possible funding policies in Horizon 2020 for the European Commission’s DG Information Society and Media (DG INFSO). Informed by a large dataset recording the details of funded projects, the simulation model is set up to reproduce and assess the funding strategies, the funded organisations and projects, and the resulting network structures of the Commission’s Framework 7 (FP7) programme. To address the evaluative questions of DG INFSO, this model, extrapolated into the future without any policy changes, is taken as an evidence-based benchmark for further experiments. Against this baseline scenario the following example policy changes are tested: (i) What if there were changes to the thematic scope of the programme? (ii) What if there were changes to the instruments of funding? (iii) What if there were changes to the overall amount of programme funding? (iv) What if there were changes to increase Small and Medium Enterprise (SME) participation? The results of these simulation experiments reveal some likely scenarios as policy options for Horizon 2020. The paper thus demonstrates that realistic modelling with a close data-to-model link can directly provide policy advice.